Tel: +44 7960 989797

Email: gro.xinortoetso@ofni

A translational tool for characterising fine anatomical structures

fineSA® is a novel and proprietary technique for characterising anatomical structures using magnetic resonance data. Data is acquired from rectangular prisms located in the anatomical region and orientation of interest using a proprietary pulse sequence. The resulting one-dimensional signal profiles are then analysed using proprietary signal processing algorithms to determine the spacing and/or size distribution of the anatomical elements of interest.

fineSA addresses a specific clinical imaging problem - while MRI scores well as an imaging modality in terms of specificity, signal to noise and absence of radiation burden (as compared with PET/SPECT and CT), it does, like ultrasound, suffer from poor spatial resolution.

Osteotronix’s fineSA software tools effectively extend the resolution of MRI by at least 10 times and are fully translational from preclinical to clinical applications. Additionally, fineSA has the advantage of very short acquisition times, (less than one minute, and in the case of liver fibrosis studies ~16 seconds) with the ability to identify repetitive structural features as small as 100 μm.

fineSA is implemented as a software package that can ultimately be installed on any MRI system, clinical or preclinical with no additional hardware requirement.

For certain applications, it is advantageous to obtain structural spectra from a number of adjacent regions; modification of the basic pulse sequence allows data to be taken from multiple regions simultaneously. The data from multiple prisms can be conveniently displayed as colour maps or by other methods. An example of data from multiple prisms in a liver study is show below; in this figure, green colours depict regions with structural spacings in the range up to 1mm, blue from 1-3mm, and red greater than 3mm.

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